Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. Although nonsynonymous SNPs in the pfk13 Kelch-repeat propeller (KREP) domain are clearly associated with artemisinin resistan...

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Detalles Bibliográficos
Autores principales: Kucharski, Michal, Wirjanata, Grennady, Nayak, Sourav, Boentoro, Josephine, Dziekan, Jerzy Michal, Assisi, Christina, van der Pluijm, Rob W., Miotto, Olivo, Mok, Sachel, Dondorp, Arjen M., Bozdech, Zbynek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901795/
https://www.ncbi.nlm.nih.gov/pubmed/36696458
http://dx.doi.org/10.1371/journal.ppat.1011118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901795/
https://www.ncbi.nlm.nih.gov/pubmed/36696458
http://dx.doi.org/10.1371/journal.ppat.1011118

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