Cargando…

Autophagy attenuates osteoarthritis in mice by inhibiting chondrocyte pyroptosis and improving subchondral bone remodeling

Osteoarthritis (OA) is an age-related degenerative disease characterized by cartilage degeneration and abnormal bone remodeling in the subchondral bone. Autophagy maintains cellular homeostasis by self-phagocytosis. However, the underlying mechanisms of autophagy on the pathological progression of O...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Jiangbo, Feng, Gangning, Yang, Yong, Ding, Dong, Ma, Long, Zhao, Xin, Chen, Xiaolei, Wang, Hui, Chen, Zhirong, Jin, Qunhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901906/ https://www.ncbi.nlm.nih.gov/pubmed/35880352 http://dx.doi.org/10.17305/bjbms.2022.7677

Ejemplares similares

Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis
por: Yan, Jiangbo, et al.
Publicado: (2022)

Dihydroartemisinin attenuates osteoarthritis by inhibiting abnormal bone remodeling and angiogenesis in subchondral bone
por: Ma, Long, et al.
Publicado: (2021)

Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation
por: Yan, Jiangbo, et al.
Publicado: (2022)

Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption
por: Ding, Dong, et al.
Publicado: (2022)

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway
por: Guo, Haohui, et al.
Publicado: (2021)

Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF-κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis
por: Ding, Dong, et al.
Publicado: (2022)

Osteoclasts secrete leukemia inhibitory factor to promote abnormal bone remodeling of subchondral bone in osteoarthritis
por: Zhao, Xin, et al.
Publicado: (2022)

Subchondral bone remodelling and osteoarthritis
por: Román-Blas, Jorge A, et al.
Publicado: (2012)

Subchondral bone remodelling in osteoarthritis
por: Donell, Simon
Publicado: (2019)

Parathyroid hormone attenuates osteoarthritis pain by remodeling subchondral bone in mice
por: Sun, Qi, et al.
Publicado: (2021)

Epigenetic Regulation of Chondrocytes and Subchondral Bone in Osteoarthritis
por: Ball, Hope C., et al.
Publicado: (2022)

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis
por: Wu, Long, et al.
Publicado: (2016)

Halofuginone Attenuates Osteoarthritis by Rescuing Bone Remodeling in Subchondral Bone Through Oral Gavage
por: Mu, Wenbo, et al.
Publicado: (2018)

Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice
por: Li, Zhen, et al.
Publicado: (2023)

Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis
por: Sun, Qi, et al.
Publicado: (2022)

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
por: Zhu, Xiaobo, et al.
Publicado: (2021)

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone
por: Yajun, Wang, et al.
Publicado: (2021)

β2-Adrenergic receptor expression in subchondral bone of patients with varus knee osteoarthritis
por: Yang, Xiaochun, et al.
Publicado: (2022)

Subchondral bone microenvironment in osteoarthritis and pain
por: Hu, Yan, et al.
Publicado: (2021)

Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology
por: Yi, Nanxing, et al.
Publicado: (2022)

Jintiange Capsules Ameliorate Osteoarthritis by Modulating Subchondral Bone Remodeling and Protecting Cartilage Against Degradation
por: Zhuang, Chenyang, et al.
Publicado: (2021)

Subchondral Bone Plate Thickening Precedes Chondrocyte Apoptosis and Cartilage Degradation in Spontaneous Animal Models of Osteoarthritis
por: Zamli, Zaitunnatakhin, et al.
Publicado: (2014)

Subchondral Bone Microarchitectural and Mineral Properties and Expression of Key Degradative Proteinases by Chondrocytes in Human Hip Osteoarthritis
por: Li, Yunfei, et al.
Publicado: (2021)

Subchondral bone architecture and quality in osteoarthritis
por: Aspden, RM
Publicado: (2004)

Targeting subchondral bone in osteoporotic osteoarthritis
por: Roman-Blas, Jorge A, et al.
Publicado: (2014)

The Importance of Subchondral Bone in the Pathophysiology of Osteoarthritis
por: Stewart, Holly L., et al.
Publicado: (2018)

Subchondral bone histology and grading in osteoarthritis
por: Aho, Olli-Matti, et al.
Publicado: (2017)

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
por: Bellido, Miriam, et al.
Publicado: (2010)

Calcium-phosphate complex increased during subchondral bone remodeling affects earlystage osteoarthritis
por: Jung, Youn-Kwan, et al.
Publicado: (2018)

Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis
por: Xu, Xiao, et al.
Publicado: (2019)

Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts
por: Zhu, Meisong, et al.
Publicado: (2022)

Inhibition of TGF–β signaling in subchondral bone mesenchymal stem cells attenuates osteoarthritis
por: Zhen, Gehua, et al.
Publicado: (2013)

Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone
por: Cui, Zhuang, et al.
Publicado: (2016)

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
por: Hu, Wenhui, et al.
Publicado: (2021)

SOST Deficiency Aggravates Osteoarthritis in Mice by Promoting Sclerosis of Subchondral Bone
por: Li, Jingyu, et al.
Publicado: (2019)

Expansion of myeloid-derived suppressor cells contributes to metabolic osteoarthritis through subchondral bone remodeling
por: Zhang, Lixia, et al.
Publicado: (2021)

Less mechanical loading attenuates osteoarthritis by reducing cartilage degeneration, subchondral bone remodelling, secondary inflammation, and activation of NLRP3 inflammasome
por: He, Zhennian, et al.
Publicado: (2020)

Microstructural analysis of subchondral bone in knee osteoarthritis
por: Holzer, L.A., et al.
Publicado: (2020)

Dickkopf-3 and β-catenin play opposite roles in the Wnt/β-catenin pathway during the abnormal subchondral bone formation of human knee osteoarthritis
por: Liang, Xuegang, et al.
Publicado: (2022)

Microstructure and mechanical properties of subchondral bone are negatively regulated by tramadol in osteoarthritis in mice
por: Ji, Chen-Chen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_35qaau48e678j6ecrrr2nd87n9