TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions

MALT1 is a core component of the CARD11-BCL10-MALT1 (CBM) signalosome, in which it acts as a scaffold and a protease to bridge T cell receptor (TCR) ligation to immune activation. As a scaffold, MALT1 binds to TRAF6, and T cell-specific TRAF6 ablation or destruction of MALT1-TRAF6 interaction provok...

Descripción completa

Detalles Bibliográficos
Autores principales: O’Neill, Thomas J., Gewies, Andreas, Seeholzer, Thomas, Krappmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902345/
https://www.ncbi.nlm.nih.gov/pubmed/36761777
http://dx.doi.org/10.3389/fimmu.2023.1111398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902345/
https://www.ncbi.nlm.nih.gov/pubmed/36761777
http://dx.doi.org/10.3389/fimmu.2023.1111398

Ejemplares similares