Osteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by the accumulation of amyloid β peptides (Aβ) and impaired glucose metabolism in the brain. Osteocalcin (OCN), an osteoblast-derived protein, has been shown to modulate brain functions but whether it has any effect...

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Detalles Bibliográficos
Autores principales: Shan, Chang, Zhang, Deng, Ma, Dong-ni, Hou, Yan-fang, Zhuang, Qian-qian, Gong, Yan-ling, Sun, Li-hao, Zhao, Hong-yan, Tao, Bei, Yang, Yu-ying, Li, Sheng-tian, Liu, Jian-min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902399/
https://www.ncbi.nlm.nih.gov/pubmed/36746932
http://dx.doi.org/10.1038/s41420-023-01343-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902399/
https://www.ncbi.nlm.nih.gov/pubmed/36746932
http://dx.doi.org/10.1038/s41420-023-01343-y

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