Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease

Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we used bio-o...

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Detalles Bibliográficos
Autores principales: Flinkman, Dani, Hong, Ye, Gnjatovic, Jelena, Deshpande, Prasannakumar, Ortutay, Zsuzsanna, Peltonen, Sirkku, Kaasinen, Valtteri, James, Peter, Coffey, Eleanor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902458/
https://www.ncbi.nlm.nih.gov/pubmed/36746972
http://dx.doi.org/10.1038/s41531-023-00460-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902458/
https://www.ncbi.nlm.nih.gov/pubmed/36746972
http://dx.doi.org/10.1038/s41531-023-00460-w

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