In silico analysis of TUBA4A mutations in Amyotrophic Lateral Sclerosis to define mechanisms of microtubule disintegration

Amyotrophic lateral sclerosis (ALS) is an inexorably progressive and degenerative disorder of motor neurons with no currently-known cure. Studies to determine the mechanism of neurotoxicity and the impact of ALS-linked mutations (SOD1, FUS, TARDP, C9ORF72, PFN1, TUBA4A and others) have greatly expan...

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Detalles Bibliográficos
Autores principales: Ganne, Akshatha, Balasubramaniam, Meenakshisundaram, Ayyadevara, Haarika, Kiaei, Lily, Shmookler Reis, Robert J., Varughese, Kottayil I., Kiaei, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902468/
https://www.ncbi.nlm.nih.gov/pubmed/36747013
http://dx.doi.org/10.1038/s41598-023-28381-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902468/
https://www.ncbi.nlm.nih.gov/pubmed/36747013
http://dx.doi.org/10.1038/s41598-023-28381-x

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