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Intratumoral heterogeneity affects tumor regression and Ki67 proliferation index in perioperatively treated gastric carcinoma

BACKGROUND: Intratumoral heterogeneity (ITH) is a major problem in gastric cancer (GC). We tested Ki67 and tumor regression for ITH after neoadjuvant/perioperative chemotherapy. METHODS: 429 paraffin blocks were obtained from 106 neoadjuvantly/perioperatively treated GCs (one to five blocks per case...

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Detalles Bibliográficos
Autores principales:	Kock am Brink, Magnus, Dunst, Laura Sophie, Behrens, Hans-Michael, Krüger, Sandra, Becker, Thomas, Röcken, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902476/ https://www.ncbi.nlm.nih.gov/pubmed/36347963 http://dx.doi.org/10.1038/s41416-022-02047-3

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