Gemcitabine promotes autophagy and lysosomal function through ERK- and TFEB-dependent mechanisms

Gemcitabine is a first-line treatment agent for pancreatic ductal adenocarcinoma (PDAC). Contributing to its cytotoxicity, this chemotherapeutic agent is primarily a DNA replication inhibitor that also induces DNA damage. However, its therapeutic effects are limited owing to chemoresistance. Evidenc...

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Detalles Bibliográficos
Autores principales: Marchand, Benoît, Poulin, Marc-Antoine, Lawson, Christine, Tai, Lee-Hwa, Jean, Steve, Boucher, Marie-Josée
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902516/
https://www.ncbi.nlm.nih.gov/pubmed/36746928
http://dx.doi.org/10.1038/s41420-023-01342-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902516/
https://www.ncbi.nlm.nih.gov/pubmed/36746928
http://dx.doi.org/10.1038/s41420-023-01342-z

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