Cargando…

Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig

Animal models are important for understanding the pathogenesis of human diseases and for developing and testing new drugs. Pigs have been widely used in the research on the cardiovascular, skin barrier, gastrointestinal, and central nervous systems as well as organ transplantation. Recently, pigs al...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Yingqi, Li, Caijuan, Wang, Wei, Li, Jiawei, Huang, Chunhui, Zheng, Xiao, Liu, Zhaoming, Song, Xichen, Chen, Yizhi, Gao, Jiale, Wu, Jianhao, Wu, Jiaxi, Tu, Zhuchi, Lai, Liangxue, Li, Xiao-Jiang, Li, Shihua, Yan, Sen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9902950/ https://www.ncbi.nlm.nih.gov/pubmed/36762127 http://dx.doi.org/10.3389/fcell.2022.1115348

Ejemplares similares

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin
por: Li, Caijuan, et al.
Publicado: (2023)

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin (Adv. Sci. 31/2023)
por: Li, Caijuan, et al.
Publicado: (2023)

Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
por: Zheng, Xiao, et al.
Publicado: (2023)

Application of CRISPR/Cas9 System in Establishing Large Animal Models
por: Lin, Yingqi, et al.
Publicado: (2022)

Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys
por: Tu, Zhuchi, et al.
Publicado: (2023)

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington’s disease
por: Hadaczek, Piotr, et al.
Publicado: (2016)

Amelioration of Muscle and Nerve Pathology in LAMA2 Muscular Dystrophy by AAV9-Mini-Agrin
por: Qiao, Chunping, et al.
Publicado: (2018)

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
por: Deverman, Benjamin E., et al.
Publicado: (2016)

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain
por: Wang, Guohao, et al.
Publicado: (2015)

Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver
por: Qiao, Chunping, et al.
Publicado: (2010)

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy
por: Chang, Renbao, et al.
Publicado: (2015)

Evaluation of an AAV9-mini-dystrophin gene therapy candidate in a rat model of Duchenne muscular dystrophy
por: Le Guiner, Caroline, et al.
Publicado: (2023)

Neuropathology of transgenic HD animal models
por: Li, Xiaojiang, et al.
Publicado: (2012)

rAAV-compatible MiniPromoters for restricted expression in the brain and eye
por: de Leeuw, Charles N., et al.
Publicado: (2016)

Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
por: Hanlon, Killian S., et al.
Publicado: (2019)

Durability of transgene expression after rAAV gene therapy
por: Muhuri, Manish, et al.
Publicado: (2022)

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
por: Subramanian, Megha, et al.
Publicado: (2023)

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model
por: Jiang, Wenxiao, et al.
Publicado: (2015)

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs
por: Xin, Jige, et al.
Publicado: (2013)

Production of transgenic pigs over-expressing the antiviral gene Mx1
por: Yan, Quanmei, et al.
Publicado: (2014)

Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9
por: Li, Hao, et al.
Publicado: (2018)

Variable expression and silencing of CRISPR-Cas9 targeted transgenes identifies the AAVS1 locus as not an entirely safe harbour
por: Bhagwan, Jamie R., et al.
Publicado: (2020)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases
por: Yang, Weili, et al.
Publicado: (2016)

Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear Transfer
por: Deng, Wei, et al.
Publicado: (2011)

A Mini-Review of Flavone Isomers Apigenin and Genistein in Prostate Cancer Treatment
por: Ji, Xiaozhen, et al.
Publicado: (2022)

Optimization of AAV expression cassettes to improve packaging capacity and transgene expression in neurons
por: Choi, Jun-Hyeok, et al.
Publicado: (2014)

Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors
por: Hollidge, Bradley S., et al.
Publicado: (2022)

AAV-p40 Bioengineering Platform for Variant Selection Based on Transgene Expression
por: Westhaus, Adrian, et al.
Publicado: (2022)

Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics
por: Su, Wenqi, et al.
Publicado: (2021)

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna
por: Hinderer, Christian, et al.
Publicado: (2014)

IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression
por: Gil-Fariña, Irene, et al.
Publicado: (2013)

Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
por: Tu, Zhuchi, et al.
Publicado: (2017)

AAV-ie enables safe and efficient gene transfer to inner ear cells
por: Tan, Fangzhi, et al.
Publicado: (2019)

CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
por: Tu, Zhuchi, et al.
Publicado: (2015)

The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression
por: Zhong, Shumei, et al.
Publicado: (2004)

PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina
por: Hickmott, Jack W, et al.
Publicado: (2016)

Directed Evolution of AAV Serotype 5 for Increased Hepatocyte Transduction and Retained Low Humoral Seroreactivity
por: Qian, Randolph, et al.
Publicado: (2020)

Evaluation of Lateral Spread of Transgene Expression following Subretinal AAV–Mediated Gene Delivery in Dogs
por: Bruewer, Ashlee R., et al.
Publicado: (2013)

Intramuscular Injection of AAV8 in Mice and Macaques Is Associated with Substantial Hepatic Targeting and Transgene Expression
por: Greig, Jenny A., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ap5ri2f0ttq25vgo0v78f338cr