Purification and structure of luminal domain C of human Niemann–Pick C1 protein

Niemann–Pick C1 protein (NPC1) is a membrane protein that primarily resides in late endosomes and lysosomes, and plays an important role in cholesterol homeostasis in the cell. The second luminal domain of NPC1 (NPC1-C) serves as the intracellular receptor for Ebola and Marburg viruses. Here, the re...

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Detalles Bibliográficos
Autores principales: Odongo, Laura, Zadrozny, Kaneil K., Diehl, William E., Luban, Jeremy, White, Judith M., Ganser-Pornillos, Barbie K., Tamm, Lukas K., Pornillos, Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903137/
https://www.ncbi.nlm.nih.gov/pubmed/36748341
http://dx.doi.org/10.1107/S2053230X23000705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903137/
https://www.ncbi.nlm.nih.gov/pubmed/36748341
http://dx.doi.org/10.1107/S2053230X23000705

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