Quantification of the purinergic P2X(7) receptor with [(11)C]SMW139 improves through correction for brain-penetrating radiometabolites

The membrane-based purinergic 7 receptor (P2X(7)R) is expressed on activated microglia and the target of the radioligand [(11)C]SMW139 for in vivo assessment of neuroinflammation. This study investigated the contribution of radiolabelled metabolites which potentially affect its quantification. Ex vi...

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Detalles Bibliográficos
Autores principales: Brumberg, Joachim, Aarnio, Richard, Forsberg, Anton, Marjamäki, Päivi, Kerstens, Vera, Moein, Mohammad M, Nag, Sangram, Wahlroos, Saara, Kassiou, Michael, Windhorst, Albert D, Halldin, Christer, Haaparanta-Solin, Merja, Fazio, Patrik, Oikonen, Vesa, Rinne, Juha O, Varrone, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903223/
https://www.ncbi.nlm.nih.gov/pubmed/36163685
http://dx.doi.org/10.1177/0271678X221126830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903223/
https://www.ncbi.nlm.nih.gov/pubmed/36163685
http://dx.doi.org/10.1177/0271678X221126830

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