A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate

[Image: see text] Imine reductases (IREDs) catalyze the asymmetric reduction of cyclic imines, but also in some cases the coupling of ketones and amines to form secondary amine products in an enzyme-catalyzed reductive amination (RedAm) reaction. Enzymatic RedAm reactions have typically used small h...

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Detalles Bibliográficos
Autores principales: Gilio, Amelia K., Thorpe, Thomas W., Heyam, Alex, Petchey, Mark R., Pogrányi, Balázs, France, Scott P., Howard, Roger M., Karmilowicz, Michael J., Lewis, Russell, Turner, Nicholas, Grogan, Gideon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903292/
https://www.ncbi.nlm.nih.gov/pubmed/36776386
http://dx.doi.org/10.1021/acscatal.2c06066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903292/
https://www.ncbi.nlm.nih.gov/pubmed/36776386
http://dx.doi.org/10.1021/acscatal.2c06066

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