Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy

[Image: see text] A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5–C-8 positions as well as allowing some variation of the vinyl ketone...

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Detalles Bibliográficos
Autores principales: Day, Aaron J., Jenkins, Timothy C., Kischkewitz, Marvin, Christensen, Kirsten E., Poole, Darren L., Donohoe, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903316/
https://www.ncbi.nlm.nih.gov/pubmed/36688518
http://dx.doi.org/10.1021/acs.orglett.2c04149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903316/
https://www.ncbi.nlm.nih.gov/pubmed/36688518
http://dx.doi.org/10.1021/acs.orglett.2c04149

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