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Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy
[Image: see text] A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5–C-8 positions as well as allowing some variation of the vinyl ketone...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903316/ https://www.ncbi.nlm.nih.gov/pubmed/36688518 http://dx.doi.org/10.1021/acs.orglett.2c04149 |