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Robust SNP-based prediction of rheumatoid arthritis through machine-learning-optimized polygenic risk score

BACKGROUND: The popular statistics-based Genome-wide association studies (GWAS) have provided deep insights into the field of complex disorder genetics. However, its clinical applicability to predict disease/trait outcomes remains unclear as statistical models are not designed to make predictions. T...

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Detalles Bibliográficos
Autores principales:	Lim, Ashley J. W., Tyniana, C. Tera, Lim, Lee Jin, Tan, Justina Wei Lynn, Koh, Ee Tzun, Chong, Samuel S., Khor, Chiea Chuen, Leong, Khai Pang, Lee, Caroline G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903430/ https://www.ncbi.nlm.nih.gov/pubmed/36750873 http://dx.doi.org/10.1186/s12967-023-03939-5

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