Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Both upregulation and downregulation by cis-regulatory elements help modulate precise gene expression. However, our understanding of repressive elements is far more limited than activating elements. To address this gap, we characterized RE1, a group of transcriptional silencers bound by REST, at gen...

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Detalles Bibliográficos
Autores principales: Mouri, Kousuke, Dewey, Hannah B., Castro, Rodrigo, Berenzy, Daniel, Kales, Susan, Tewhey, Ryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903721/
https://www.ncbi.nlm.nih.gov/pubmed/36777181
http://dx.doi.org/10.1016/j.xgen.2022.100234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903721/
https://www.ncbi.nlm.nih.gov/pubmed/36777181
http://dx.doi.org/10.1016/j.xgen.2022.100234

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