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Whole-genome functional characterization of RE1 silencers using a modified massively parallel reporter assay
Both upregulation and downregulation by cis-regulatory elements help modulate precise gene expression. However, our understanding of repressive elements is far more limited than activating elements. To address this gap, we characterized RE1, a group of transcriptional silencers bound by REST, at gen...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903721/ https://www.ncbi.nlm.nih.gov/pubmed/36777181 http://dx.doi.org/10.1016/j.xgen.2022.100234 |