Identification of PCSK9-like human gene knockouts using metabolomics, proteomics, and whole-genome sequencing in a consanguineous population

Natural human knockouts of genes associated with desirable outcomes, such as PCSK9 with low levels of LDL-cholesterol, can lead to the discovery of new drug targets and treatments. Rare loss-of-function variants are more likely to be found in the homozygous state in consanguineous populations, and d...

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Detalles Bibliográficos
Autores principales: Belkadi, Aziz, Thareja, Gaurav, Abbaszadeh, Fatemeh, Badii, Ramin, Fauman, Eric, Albagha, Omar M.E., Suhre, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903797/
https://www.ncbi.nlm.nih.gov/pubmed/36777185
http://dx.doi.org/10.1016/j.xgen.2022.100218

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9903797/
https://www.ncbi.nlm.nih.gov/pubmed/36777185
http://dx.doi.org/10.1016/j.xgen.2022.100218

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