Selective CD28 blockade impacts T cell differentiation during homeostatic reconstitution following lymphodepletion

INTRODUCTION: Costimulation blockade targeting the CD28 pathway provides improved long-term renal allograft survival compared to calcineurin inhibitors but may be limited as CTLA-4-Ig (abatacept, belatacept) blocks both CD28 costimulation and CTLA-4 coinhibition. Directly targeting CD28 while leavin...

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Detalles Bibliográficos
Autores principales: Habib, Jakob G., Liu, Danya, Crepeau, Rebecca M., Wagener, Maylene E., Ford, Mandy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904166/
https://www.ncbi.nlm.nih.gov/pubmed/36761170
http://dx.doi.org/10.3389/fimmu.2022.1081163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904166/
https://www.ncbi.nlm.nih.gov/pubmed/36761170
http://dx.doi.org/10.3389/fimmu.2022.1081163

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