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Rational design of Harakiri (HRK)-derived constrained peptides as BCL-x(L) inhibitors
Using the HRK BH3 domain, sequence hybridization and in silico methods we show dibromomaleimide staple scanning can be used to inform the design of BCL-x(L) selective peptidomimetic ligands. These HRK-inspired reagents may serve as starting points for the discovery of therapeutics to target BCL-x(L)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9904277/ https://www.ncbi.nlm.nih.gov/pubmed/36692261 http://dx.doi.org/10.1039/d2cc06029a |