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Analysis of causes for poor persistence of CAR-T cell therapy in vivo

Chimeric antigen receptor T-cell (CAR-T-cell) therapy has been well researched to date because of its ability to target malignant tumor cells. The most common CAR-T cells are CD19 CAR-T cells, which play a large role in B-cell leukemia treatment. However, most CAR-T cells are associated with relapse...

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Detalles Bibliográficos
Autores principales: Kong, Yingjie, Tang, Ling, You, Yong, Li, Qing, Zhu, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905114/
https://www.ncbi.nlm.nih.gov/pubmed/36761742
http://dx.doi.org/10.3389/fimmu.2023.1063454