Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby it degrades longer Aβ peptides into a non‑tox...

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Detalles Bibliográficos
Autores principales: Ulku, Irem, Liebsch, Filip, Akerman, S. Can, Schulz, Jana F., Kulic, Luka, Hock, Christoph, Pietrzik, Claus, Di Spiezio, Alessandro, Thinakaran, Gopal, Saftig, Paul, Multhaup, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905473/
https://www.ncbi.nlm.nih.gov/pubmed/36750595
http://dx.doi.org/10.1038/s41598-023-28846-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905473/
https://www.ncbi.nlm.nih.gov/pubmed/36750595
http://dx.doi.org/10.1038/s41598-023-28846-z

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