Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers

Expression or phosphorylation levels of leucine-rich repeat kinase 2 (LRRK2) and its Rab substrates have strong potential as disease or pharmacodynamic biomarkers. The main objective of this study is therefore to assess the LRRK2-Rab pathway for use as biomarkers in human, non-human primate (NHP) an...

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Detalles Bibliográficos
Autores principales: Taymans, Jean-Marc, Mutez, Eugénie, Sibran, William, Vandewynckel, Laurine, Deldycke, Claire, Bleuse, Séverine, Marchand, Antoine, Sarchione, Alessia, Leghay, Coline, Kreisler, Alexandre, Simonin, Clémence, Koprich, James, Baille, Guillaume, Defebvre, Luc, Dujardin, Kathy, Destée, Alain, Chartier-Harlin, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905493/
https://www.ncbi.nlm.nih.gov/pubmed/36750568
http://dx.doi.org/10.1038/s41531-023-00445-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905493/
https://www.ncbi.nlm.nih.gov/pubmed/36750568
http://dx.doi.org/10.1038/s41531-023-00445-9

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