Polo-like kinase 4 inhibitor CFI-400945 inhibits carotid arterial neointima formation but increases atherosclerosis

Neointima lesion and atherosclerosis are proliferative vascular diseases associated with deregulated proliferation of vascular smooth muscle cells (SMCs). CFI-400945 is a novel, highly effective anticancer drug that inhibits polo-like kinase 4 (PLK4) and targets mitosis. In this study, we aim to inv...

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Detalles Bibliográficos
Autores principales: Sun, Jiaxing, Belke, Darrell, Gui, Yu, Chen, Yong-Xiang, Zhou, Shenghua, Zheng, Xi-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905587/
https://www.ncbi.nlm.nih.gov/pubmed/36750553
http://dx.doi.org/10.1038/s41420-023-01305-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905587/
https://www.ncbi.nlm.nih.gov/pubmed/36750553
http://dx.doi.org/10.1038/s41420-023-01305-4

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