RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression

Ribosome biogenesis (RiBi) plays a pivotal role in carcinogenesis by regulating protein translation and stress response. Here, we find that RRP15, a nucleolar protein critical for RiBi and checkpoint control, is frequently upregulated in primary CRCs and higher RRP15 expression positively correlated...

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Detalles Bibliográficos
Autores principales: Dong, Zhixiong, Li, Jinhai, Dai, Wenqing, Yu, Dongbo, Zhao, Youjuan, Liu, Shuanghui, Li, Xuanwen, Zhang, Zhengzheng, Zhang, Rui, Liang, Xue, Kong, Qingran, Jin, Shengnan, Jiang, Hao, Jiang, Wei, Ding, Chunming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905588/
https://www.ncbi.nlm.nih.gov/pubmed/36750557
http://dx.doi.org/10.1038/s41419-023-05578-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905588/
https://www.ncbi.nlm.nih.gov/pubmed/36750557
http://dx.doi.org/10.1038/s41419-023-05578-6

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