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Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine

INTRODUCTION: High intracellular concentrations of adenosine and 2’-deoxyadenosine have been suggested to be an important mediator of cell death. The aim of the present study was to characterize adenosine-induced death in insulin-producing beta-cells, at control and high glucose + palmitate-induced...

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Detalles Bibliográficos
Autores principales: Ngamjariyawat, Anongnad, Cen, Jing, Said, Romain, Incedal, Ceren, Idevall-Hagren, Olof, Welsh, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905624/
https://www.ncbi.nlm.nih.gov/pubmed/36761184
http://dx.doi.org/10.3389/fendo.2023.1060675