Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ‘framework’ residues to recognize specific Human Leuc...

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Detalles Bibliográficos
Autores principales: Papadaki, Georgia F., Ani, Omar, Florio, Tyler J., Young, Michael C., Danon, Julia N., Sun, Yi, Dersh, Devin, Sgourakis, Nikolaos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905809/
https://www.ncbi.nlm.nih.gov/pubmed/36761745
http://dx.doi.org/10.3389/fimmu.2023.1116906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905809/
https://www.ncbi.nlm.nih.gov/pubmed/36761745
http://dx.doi.org/10.3389/fimmu.2023.1116906

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