Cargando…

Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy

DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing. Most of these helicases are upregulated in various cancers and mutations in so...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arna, Ananna Bhadra, Patel, Hardikkumar, Singh, Ravi Shankar, Vizeacoumar, Frederick S., Kusalik, Anthony, Freywald, Andrew, Vizeacoumar, Franco J., Wu, Yuliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9905851/ https://www.ncbi.nlm.nih.gov/pubmed/36761420 http://dx.doi.org/10.3389/fonc.2022.1087989

Ejemplares similares

Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer
por: Kirzinger, Morgan W. B., et al.
Publicado: (2019)

Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment
por: Paul, James M., et al.
Publicado: (2016)

The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment
por: El Zawily, Amr, et al.
Publicado: (2017)

Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia
por: K. Bhanumathy, Kalpana, et al.
Publicado: (2021)

A Drug Repurposing Screen Identifies Fludarabine Phosphate as a Potential Therapeutic Agent for N-MYC Overexpressing Neuroendocrine Prostate Cancers
por: Elhasasna, Hussain, et al.
Publicado: (2022)

The CINs of Polo-Like Kinase 1 in Cancer
por: Cunningham, Chelsea E., et al.
Publicado: (2020)

Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer
por: Zheng, Bichun, et al.
Publicado: (2023)

Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability
por: Jing, Anqi, et al.
Publicado: (2018)

Mining the plasma-proteome associated genes in patients with gastro-esophageal cancers for biomarker discovery
por: Vizeacoumar, Frederick S., et al.
Publicado: (2021)

Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
por: Shinriki, Satoru, et al.
Publicado: (2022)

DEAD-box RNA helicases in Escherichia coli
por: Iost, Isabelle, et al.
Publicado: (2006)

Unraveling the ‘DEAD-box’ helicases of Plasmodium falciparum
por: Tuteja, Renu, et al.
Publicado: (2006)

DEAD-Box RNA Helicases and Genome Stability
por: Cargill, Michael, et al.
Publicado: (2021)

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
por: Wong, Lai, et al.
Publicado: (2020)

An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer
por: Auslander, Noam, et al.
Publicado: (2017)

EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours
por: Toosi, Behzad M., et al.
Publicado: (2018)

Selective Pharmacological Targeting of a DEAD Box RNA Helicase
por: Lindqvist, Lisa, et al.
Publicado: (2008)

Vasa-Like DEAD-Box RNA Helicases of Schistosoma mansoni
por: Skinner, Danielle E., et al.
Publicado: (2012)

Comparative Structural Analysis of Human DEAD-Box RNA Helicases
por: Schütz, Patrick, et al.
Publicado: (2010)

Wait and Capture: Unwinding the Strategy of a DEAD-Box Helicase
por: Robinson, Richard
Publicado: (2014)

In vivo mapping of the functional regions of the DEAD-box helicase Vasa
por: Dehghani, Mehrnoush, et al.
Publicado: (2015)

DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
por: Taschuk, Frances, et al.
Publicado: (2020)

Genera specific distribution of DEAD-box RNA helicases in cyanobacteria
por: Whitford, Denise S., et al.
Publicado: (2021)

DEAD-box helicases modulate dicing body formation in Arabidopsis
por: Li, Qi, et al.
Publicado: (2021)

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
por: Chafe, Shawn C., et al.
Publicado: (2021)

DDX41 is required for cGAS-STING activation against DNA virus infection
por: Singh, Ravi Shankar, et al.
Publicado: (2022)

Molecular characterization of an MLL1 fusion and its role in chromosomal instability
por: Parameswaran, Sreejit, et al.
Publicado: (2018)

The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation
por: El Zawily, Amr M., et al.
Publicado: (2016)

DEAD/DExH-Box RNA Helicases in Selected Human Parasites
por: Marchat, Laurence A., et al.
Publicado: (2015)

Diverse Roles of DEAD/DEAH-Box Helicases in Innate Immunity and Diseases
por: Perčulija, Vanja, et al.
Publicado: (2019)

DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy
por: Zhang, Lu, et al.
Publicado: (2021)

The DEAD-Box RNA Helicase Ded1 Is Associated with Translating Ribosomes
por: Yeter-Alat, Hilal, et al.
Publicado: (2023)

Identification of novel genes involved in apoptosis of HIV-infected macrophages using unbiased genome-wide screening
por: Dong, Simon X. M., et al.
Publicado: (2021)

A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in Drosophila
por: Cauchi, Ruben J., et al.
Publicado: (2008)

The DEAD-box helicase DDX3 supports the assembly of functional 80S ribosomes
por: Geissler, Rene, et al.
Publicado: (2012)

Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis
por: Cauchi, Ruben J
Publicado: (2012)

Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28
por: Möhlmann, Sina, et al.
Publicado: (2014)

The DEAD/DEAH box helicase, DDX11, is essential for the survival of advanced melanomas
por: Bhattacharya, Chitralekha, et al.
Publicado: (2012)

Integrated Analysis of DEAD-Box Helicase 56: A Potential Oncogene in Osteosarcoma
por: Zhu, Chen, et al.
Publicado: (2020)

The emerging role of DEAD/H-box helicases in hepatitis B virus infection
por: You, Hongjuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_sf1i8vqo3ak0fc3gqjqhsikq6m