Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in the NOTCH3 gene, resulting in a mutated NOTCH3 re...

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Detalles Bibliográficos
Autores principales: Oliveira, Daniel V, Coupland, Kirsten G, Shao, Wenchao, Jin, Shaobo, Del Gaudio, Francesca, Wang, Sailan, Fox, Rhys, Rutten, Julie W, Sandin, Johan, Zetterberg, Henrik, Lundkvist, Johan, Lesnik Oberstein, Saskia AJ, Lendahl, Urban, Karlström, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906330/
https://www.ncbi.nlm.nih.gov/pubmed/36524456
http://dx.doi.org/10.15252/emmm.202216556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906330/
https://www.ncbi.nlm.nih.gov/pubmed/36524456
http://dx.doi.org/10.15252/emmm.202216556

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