Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine

BACKGROUND: Immune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating melanoma-reactive T cells, but little is known about vaccine-induced circulating lymphocytes (viCLs) homing to tumor or whether interventions are needed to enh...

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Detalles Bibliográficos
Autores principales: Tran, Christine A, Lynch, Kevin T, Meneveau, Max O, Katyal, Priya, Olson, Walter C, Slingluff,, Craig L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906378/
https://www.ncbi.nlm.nih.gov/pubmed/36746511
http://dx.doi.org/10.1136/jitc-2022-005952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906378/
https://www.ncbi.nlm.nih.gov/pubmed/36746511
http://dx.doi.org/10.1136/jitc-2022-005952

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