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Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine

BACKGROUND: Immune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating melanoma-reactive T cells, but little is known about vaccine-induced circulating lymphocytes (viCLs) homing to tumor or whether interventions are needed to enh...

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Detalles Bibliográficos
Autores principales:	Tran, Christine A, Lynch, Kevin T, Meneveau, Max O, Katyal, Priya, Olson, Walter C, Slingluff,, Craig L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906378/ https://www.ncbi.nlm.nih.gov/pubmed/36746511 http://dx.doi.org/10.1136/jitc-2022-005952

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