Amorphous Drug–Polymer Salts: Maximizing Proton Transfer to Enhance Stability and Release

[Image: see text] An amorphous drug–polymer salt (ADPS) can be remarkably stable against crystallization at high temperature and humidity (e.g., 40°C/75% RH) and provide fast release. Here, we report that process conditions strongly influence the degree of proton transfer (salt formation) between a...

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Detalles Bibliográficos
Autores principales: Neusaenger, Amy Lan, Yao, Xin, Yu, Junguang, Kim, Soojin, Hui, Ho-Wah, Huang, Lian, Que, Chailu, Yu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906740/
https://www.ncbi.nlm.nih.gov/pubmed/36668815
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9906740/
https://www.ncbi.nlm.nih.gov/pubmed/36668815
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00942

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