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SLGNN: synthetic lethality prediction in human cancers based on factor-aware knowledge graph neural network
MOTIVATION: Synthetic lethality (SL) is a form of genetic interaction that can selectively kill cancer cells without damaging normal cells. Exploiting this mechanism is gaining popularity in the field of targeted cancer therapy and anticancer drug development. Due to the limitations of identifying S...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907046/ https://www.ncbi.nlm.nih.gov/pubmed/36645245 http://dx.doi.org/10.1093/bioinformatics/btad015 |