Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii

New antimicrobials are needed for the treatment of extensively drug-resistant Acinetobacter baumannii. The de novo pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated drug target for malaria and human autoimmune diseases. We provide genetic evidence that A. baumannii D...

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Detalles Bibliográficos
Autores principales: Russo, Thomas A., Umland, Timothy C., Deng, Xiaoyi, El Mazouni, Farah, Kokkonda, Sreekanth, Olson, Ruth, Carlino-MacDonald, Ulrike, Beanan, Janet, Alvarado, Cassandra L., Tomchick, Diana R., Hutson, Alan, Chen, Hong, Posner, Bruce, Rathod, Pradipsinh K., Charman, Susan A., Phillips, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907071/
https://www.ncbi.nlm.nih.gov/pubmed/36512492
http://dx.doi.org/10.1073/pnas.2213116119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907071/
https://www.ncbi.nlm.nih.gov/pubmed/36512492
http://dx.doi.org/10.1073/pnas.2213116119

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