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A genetically encoded fluorescent sensor for manganese(II), engineered from lanmodulin

The design of selective metal-binding sites is a challenge in both small-molecule and macromolecular chemistry. Selective recognition of manganese (II)—the first-row transition metal ion that tends to bind with the lowest affinity to ligands, as described by the Irving-Williams series—is particularl...

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Detalles Bibliográficos
Autores principales: Park, Jennifer, Cleary, Michael B., Li, Danyang, Mattocks, Joseph A., Xu, Jiansong, Wang, Huan, Mukhopadhyay, Somshuvra, Gale, Eric M., Cotruvo, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907080/
https://www.ncbi.nlm.nih.gov/pubmed/36508659
http://dx.doi.org/10.1073/pnas.2212723119