Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer

Synthetic lethality is a powerful approach for targeting oncogenic drivers in cancer. Recent studies revealed that cancer cells with microsatellite instability (MSI) require Werner (WRN) helicase for survival; however, the underlying mechanism remains unclear. In this study, we found that WRN deplet...

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Detalles Bibliográficos
Autores principales: Hao, Suisui, Tong, Jingshan, Jha, Anupma, Risnik, Denise, Lizardo, Darleny, Lu, Xinyan, Goel, Ajay, Opresko, Patricia L., Yu, Jian, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907101/
https://www.ncbi.nlm.nih.gov/pubmed/36508676
http://dx.doi.org/10.1073/pnas.2211775119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907101/
https://www.ncbi.nlm.nih.gov/pubmed/36508676
http://dx.doi.org/10.1073/pnas.2211775119

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