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Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer

Synthetic lethality is a powerful approach for targeting oncogenic drivers in cancer. Recent studies revealed that cancer cells with microsatellite instability (MSI) require Werner (WRN) helicase for survival; however, the underlying mechanism remains unclear. In this study, we found that WRN deplet...

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Detalles Bibliográficos
Autores principales:	Hao, Suisui, Tong, Jingshan, Jha, Anupma, Risnik, Denise, Lizardo, Darleny, Lu, Xinyan, Goel, Ajay, Opresko, Patricia L., Yu, Jian, Zhang, Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907101/ https://www.ncbi.nlm.nih.gov/pubmed/36508676 http://dx.doi.org/10.1073/pnas.2211775119

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