Formation of extramembrane β-strands controls dimerization of transmembrane helices in amyloid precursor protein C99

The 99-residue C-terminal domain of amyloid precursor protein (APP-C99), precursor to amyloid beta (Aβ), is a transmembrane (TM) protein containing intrinsically disordered N- and C-terminal extramembrane domains. Using molecular dynamics (MD) simulations, we show that the structural ensemble of the...

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Detalles Bibliográficos
Autores principales: Pantelopulos, George A., Matsuoka, Daisuke, Hutchison, James M., Sanders, Charles R., Sugita, Yuji, Straub, John E., Thirumalai, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907117/
https://www.ncbi.nlm.nih.gov/pubmed/36538482
http://dx.doi.org/10.1073/pnas.2212207119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907117/
https://www.ncbi.nlm.nih.gov/pubmed/36538482
http://dx.doi.org/10.1073/pnas.2212207119

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