Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2

Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2 infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells. Mechanistically, this short-range sensing by pDCs...

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Detalles Bibliográficos
Autores principales: Venet, Manon, Ribeiro, Margarida Sa, Décembre, Elodie, Bellomo, Alicia, Joshi, Garima, Nuovo, Célia, Villard, Marine, Cluet, David, Perret, Magali, Pescamona, Rémi, Paidassi, Helena, Walzer, Thierry, Allatif, Omran, Belot, Alexandre, Trouillet-Assant, Sophie, Ricci, Emiliano P., Dreux, Marlène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907212/
https://www.ncbi.nlm.nih.gov/pubmed/36755036
http://dx.doi.org/10.1038/s41467-023-36140-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907212/
https://www.ncbi.nlm.nih.gov/pubmed/36755036
http://dx.doi.org/10.1038/s41467-023-36140-9

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