Cargando…

Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2

Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2 infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells. Mechanistically, this short-range sensing by pDCs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Venet, Manon, Ribeiro, Margarida Sa, Décembre, Elodie, Bellomo, Alicia, Joshi, Garima, Nuovo, Célia, Villard, Marine, Cluet, David, Perret, Magali, Pescamona, Rémi, Paidassi, Helena, Walzer, Thierry, Allatif, Omran, Belot, Alexandre, Trouillet-Assant, Sophie, Ricci, Emiliano P., Dreux, Marlène
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907212/ https://www.ncbi.nlm.nih.gov/pubmed/36755036 http://dx.doi.org/10.1038/s41467-023-36140-9

Ejemplares similares

Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses
por: Webster, Brian, et al.
Publicado: (2018)

Sensing of cell-associated HTLV by plasmacytoid dendritic cells is regulated by dense β-galactoside glycosylation
por: Assil, Sonia, et al.
Publicado: (2019)

Sensing of Immature Particles Produced by Dengue Virus Infected Cells Induces an Antiviral Response by Plasmacytoid Dendritic Cells
por: Décembre, Elodie, et al.
Publicado: (2014)

Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients
por: Goncalves, David, et al.
Publicado: (2021)

A third vaccine dose equalises the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Lyon, France, December 2021 to March 2022
por: Guibert, Nicolas, et al.
Publicado: (2023)

Type I IFN immunoprofiling in COVID-19 patients
por: Trouillet-Assant, Sophie, et al.
Publicado: (2020)

Immature particles and capsid-free viral RNA produced by Yellow fever virus-infected cells stimulate plasmacytoid dendritic cells to secrete interferons
por: Sinigaglia, Laura, et al.
Publicado: (2018)

Evaluation of TTV replication as a biomarker of immune checkpoint inhibitors efficacy in melanoma patients
por: Pescarmona, Rémi, et al.
Publicado: (2021)

Type‐I Interferon assessment in 45 minutes using the FilmArray(®) PCR platform in SARS‐CoV‐2 and other viral infections
por: Mommert, Marine, et al.
Publicado: (2021)

Interplay between SARS-CoV-2 and the type I interferon response
por: Sa Ribero, Margarida, et al.
Publicado: (2020)

Protracted viral shedding and viral load are associated with ICU mortality in Covid-19 patients with acute respiratory failure
por: Bitker, L., et al.
Publicado: (2020)

Correction: Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs
por: Lopez, Jonathan, et al.
Publicado: (2021)

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs
por: Lopez, Jonathan, et al.
Publicado: (2021)

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion
por: Marotel, Marie, et al.
Publicado: (2021)

Ribosome dynamics and mRNA turnover, a complex relationship under constant cellular scrutiny
por: Morris, Christelle, et al.
Publicado: (2021)

Refining “Long-COVID” by a Prospective Multimodal Evaluation of Patients with Long-Term Symptoms Attributed to SARS-CoV-2 Infection
por: Scherlinger, Marc, et al.
Publicado: (2021)

A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm
por: Pinto-Almeida, Teresa, et al.
Publicado: (2012)

Source of Circulating Pentraxin 3 in Septic Shock Patients
por: Albert Vega, Chloé, et al.
Publicado: (2019)

Translation of SARS-CoV-2 gRNA Is Extremely Efficient and Competitive despite a High Degree of Secondary Structures and the Presence of an uORF
por: Condé, Lionel, et al.
Publicado: (2022)

A Case of Type 2 Hypersensitivity to Rasburicase Diagnosed with a Natural Killer Cell Activation Assay
por: Viel, Sébastien, et al.
Publicado: (2018)

One-Year Follow-Up of Natural Killer Cell Activity in Multiple Myeloma Patients Treated With Adjuvant Lenalidomide Therapy
por: Besson, Laurie, et al.
Publicado: (2018)

Palatal plasmacytoid myoepithelioma
por: Sethi, Divya, et al.
Publicado: (2012)

Impact of the Autophagy Machinery on Hepatitis C Virus Infection
por: Dreux, Marlène, et al.
Publicado: (2011)

Engelures associées au COVID : plus de lien de causalité avec le virus SARS-CoV-2 et moins d’évidence pour une réponse systémique augmentée de l’interféron de type 1
por: Bessis, D., et al.
Publicado: (2022)

Deciphering heterogeneity of septic shock patients using immune functional assays: a proof of concept study
por: Albert Vega, Chloé, et al.
Publicado: (2020)

Adaptation to host cell environment during experimental evolution of Zika virus
por: Grass, Vincent, et al.
Publicado: (2022)

Assessing mycoplasma contamination of cell cultures by qPCR using a set of universal primer pairs targeting a 1.5 kb fragment of 16S rRNA genes
por: Jean, Audrey, et al.
Publicado: (2017)

DGINN, an automated and highly-flexible pipeline for the detection of genetic innovations on protein-coding genes
por: Picard, Lea, et al.
Publicado: (2020)

A Simple-to-Perform ifn-γ mRNA Gene Expression Assay on Whole Blood Accurately Appraises Varicella Zoster Virus-Specific Cell-Mediated Immunity After Allogeneic Hematopoietic Stem Cell Transplantation
por: Boccard, Mathilde, et al.
Publicado: (2022)

Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine
por: Albert-Vega, Chloé, et al.
Publicado: (2018)

Plasmacytoid Dendritic Cells in Atherosclerosis
por: Döring, Yvonne, et al.
Publicado: (2012)

Plasmacytoid dendritic cells in dermatology()()
por: Dias de Oliveira, Natasha Favoretto, et al.
Publicado: (2021)

Plasmacytoid dendritic cell neoplasms
por: Lee, Yoo Jin, et al.
Publicado: (2023)

Regulation of the Host Antiviral State by Intercellular Communications
por: Assil, Sonia, et al.
Publicado: (2015)

New perspectives on the regulation of germinal center reaction via αvβ8- mediated activation of TGFβ
por: This, Sébastien, et al.
Publicado: (2022)

Human Monocyte-Derived Osteoclasts Are Targeted by Staphylococcal Pore-Forming Toxins and Superantigens
por: Flammier, Sacha, et al.
Publicado: (2016)

A novel assessment method for COVID-19 humoral immunity duration using serial measurements in naturally infected and vaccinated subjects
por: de Boer, Jasper, et al.
Publicado: (2022)

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
por: Marçais, Antoine, et al.
Publicado: (2017)

Blastic plasmacytoid dendritic cell neoplasm
por: Lencastre, André, et al.
Publicado: (2013)

Blastic plasmacytoid dendritic cell neoplasm
por: Rai, Manoj Ponadka, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_l2ajqvg15r6fs2dhdqnnembirf