TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors

Metastatic Leydig cell tumors (LCT) are rare, difficult to treat malignancies without known underlying molecular-genetic events. We profiled 27 LCT cases using NGS and immunohistochemistry. Our study identified TERT gene fusions as a main genetic alteration and a potential therapeutic target in LCT....

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Detalles Bibliográficos
Autores principales: Kruslin, Bozo, Gatalica, Zoran, Hes, Ondrej, Skenderi, Faruk, Miettinen, Markku, Contreras, Elma, Xiu, Joanne, Ellis, Michelle, Florento, Elena, Vranic, Semir, Swensen, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907364/
https://www.ncbi.nlm.nih.gov/pubmed/33741265
http://dx.doi.org/10.1016/j.clgc.2021.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907364/
https://www.ncbi.nlm.nih.gov/pubmed/33741265
http://dx.doi.org/10.1016/j.clgc.2021.02.002

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