Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates

PURPOSE: C1q and the classical complement cascade are key regulators of synaptic pruning, and their aberrant activation has been implicated in neurodegenerative ophthalmic diseases including geographic atrophy and glaucoma. The antigen-binding fragment antibody ANX007 specifically recognizes globula...

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Detalles Bibliográficos
Autores principales: Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K., Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Retina
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907371/
https://www.ncbi.nlm.nih.gov/pubmed/36729444
http://dx.doi.org/10.1167/iovs.64.2.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907371/
https://www.ncbi.nlm.nih.gov/pubmed/36729444
http://dx.doi.org/10.1167/iovs.64.2.3

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