Cargando…

Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates

PURPOSE: C1q and the classical complement cascade are key regulators of synaptic pruning, and their aberrant activation has been implicated in neurodegenerative ophthalmic diseases including geographic atrophy and glaucoma. The antigen-binding fragment antibody ANX007 specifically recognizes globula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grover, Anita, Sankaranarayanan, Sethu, Mathur, Vidhu, Suri, Poojan, Qiu, Haiyan, Andrews-Zwilling, Yaisa, Mease, Kirsten, Taylor, Lori K., Cahir-McFarland, Ellen, Keswani, Sanjay, Yednock, Ted
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Retina
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907371/ https://www.ncbi.nlm.nih.gov/pubmed/36729444 http://dx.doi.org/10.1167/iovs.64.2.3

Ejemplares similares

Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease: Results from Phase I Studies in Glaucoma
por: Sun, Yang, et al.
Publicado: (2023)

A Spontaneous Nonhuman Primate Model of Myopic Foveoschisis
por: Sin, Tzu-Ni, et al.
Publicado: (2023)

Quantifying burden of intravitreal injections: questionnaire assessment of life impact of treatment by intravitreal injections (QUALITII)
por: Wang, Rui, et al.
Publicado: (2022)

A Novel Device for Suprachoroidal Drug Delivery to Retina: Evaluation in Nonhuman Primates
por: Rotenstreich, Ygal, et al.
Publicado: (2023)

Localized Structural and Functional Deficits in a Nonhuman Primate Model of Outer Retinal Atrophy
por: Liu, Ying V., et al.
Publicado: (2021)

Extensive Sub-RPE Complement Deposition in a Nonhuman Primate Model of Early-Stage Diabetic Retinopathy
por: Fan, Shuxin, et al.
Publicado: (2021)

Active Transport and Ocular Distribution of Intravitreally Injected Liposomes
por: Eriksen, Anne Zebitz, et al.
Publicado: (2023)

Questionnaire to Assess Life Impact of Treatment by Intravitreal Injections (QUALITII): Development of a patient-reported measure to assess treatment burden of repeat intravitreal injections
por: McClard, Cynthia K, et al.
Publicado: (2021)

Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates
por: McGill, Trevor J., et al.
Publicado: (2018)

Analysis of Microvasculature in Nonhuman Primate Macula With Acute Elevated Intraocular Pressure Using Optical Coherence Tomography Angiography
por: Choi, Mihyun, et al.
Publicado: (2021)

Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection
por: Zhang, Yu, et al.
Publicado: (2018)

Intravitreal Fluocinolone Acetonide May Decelerate Diabetic Retinal Neurodegeneration
por: Lynch, Stephanie K., et al.
Publicado: (2019)

Turnover of Microaneurysms After Intravitreal Injections of Faricimab for Diabetic Macular Edema
por: Takamura, Yoshihiro, et al.
Publicado: (2023)

Controlled Release of Dexamethasone From an Intravitreal Delivery System Using Porous Silicon Dioxide
por: Hou, Huiyuan, et al.
Publicado: (2016)

Randomized Trial of Treat-and-Extend Intravitreal Aflibercept for Radiation Retinopathy: 1-Year Outcomes
por: Trejo Corona, Stephanie, et al.
Publicado: (2023)

Cluster of symptomatic silicone oil droplets following intravitreal injections: a 1-year observational study
por: Sivertsen, Magne Sand, et al.
Publicado: (2021)

Dexamethasone intravitreal implant in diabetic macular oedema refractory to anti-vascular endothelial growth factors: the AUSSIEDEX study
por: Mitchell, Paul, et al.
Publicado: (2023)

Extended Intravitreal Rabbit Eye Residence of Nanoparticles Conjugated With Cationic Arginine Peptides for Intraocular Drug Delivery: In Vivo Imaging
por: Melgar-Asensio, Ignacio, et al.
Publicado: (2018)

Intravitreal AAV2.COMP-Ang1 Attenuates Deep Capillary Plexus Expansion in the Aged Diabetic Mouse Retina
por: Carroll, Lara S., et al.
Publicado: (2019)

Intravitreal Short-Hairpin RNA Attenuated Adeno-Associated Virus–Induced Knockdown of Amphiregulin and Axial Elongation in Experimental Myopia
por: Dong, Li, et al.
Publicado: (2023)

Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes
por: Adu-Agyeiwaah, Yvonne, et al.
Publicado: (2023)

Intravitreal anti-vascular endothelial growth factor for the treatment of chronic central serous retinopathy: a meta-analysis of the literature
por: Palakkamanil, Mathew, et al.
Publicado: (2023)

Improvement of Photoreceptor Targeting via Intravitreal Delivery in Mouse and Human Retina Using Combinatory rAAV2 Capsid Mutant Vectors
por: Reid, Christopher A., et al.
Publicado: (2017)

A Long-Term Safety and Efficacy Report on Intravitreal Delivery of Adipose Stem Cells and Secretome on Visual Deficits After Traumatic Brain Injury
por: Rasiah, Pratheepa Kumari, et al.
Publicado: (2022)

Comparison of intravitreal injection of ranibizumab versus bevacizumab for treatment of type 1 and aggressive retinopathy of prematurity in rural Egypt. A randomized clinical trial
por: Tawfik, Ghada Mahmoud, et al.
Publicado: (2022)

Subretinal Rather Than Intravitreal Adeno-Associated Virus–Mediated Delivery of a Complement Alternative Pathway Inhibitor Is Effective in a Mouse Model of RPE Damage
por: Annamalai, Balasubramaniam, et al.
Publicado: (2021)

Tear Fluid Angiogenic Factors: Potential Noninvasive Biomarkers for Retinopathy of Prematurity Screening in Preterm Infants
por: Vinekar, Anand, et al.
Publicado: (2021)

Comparing vision and macular thickness in neovascular age-related macular degeneration, diabetic macular oedema and retinal vein occlusion patients treated with intravitreal antivascular endothelial growth factor injections in clinical practice
por: Gurung, Rajya L, et al.
Publicado: (2021)

The anx/anx Mouse – A Valuable Resource in Anorexia Nervosa Research
por: Nilsson, Ida A. K.
Publicado: (2019)

P1552: A PHASE 2, OPEN-LABEL STUDY TO ASSESS SAFETY, TOLERABILITY, AND CLINICAL EFFECT OF ANX005 IN PATIENTS WITH WARM AUTOIMMUNE HEMOLYTIC ANEMIA AND EVIDENCE OF COMPLEMENT ACTIVATION
por: Jaeger, U., et al.
Publicado: (2022)

Phase 1B study of the safety and tolerability of the mineralocorticoid fludrocortisone acetate in patients with geographical atrophy
por: Hong, Thomas, et al.
Publicado: (2022)

Vision Recovery and Connectivity by Fetal Retinal Sheet Transplantation in an Immunodeficient Retinal Degenerate Rat Model
por: Seiler, Magdalene J., et al.
Publicado: (2017)

Prognostic impact of AnxA1 and AnxA2 gene expression in triple-negative breast cancer
por: Gibbs, Lee D., et al.
Publicado: (2017)

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration
por: Jiao, Haihan, et al.
Publicado: (2018)

Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling
por: Gianesini, Coralie, et al.
Publicado: (2016)

Extrafoveal Cone Packing in Eyes With a History of Retinopathy of Prematurity
por: Ramamirtham, Ramkumar, et al.
Publicado: (2016)

(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism
por: Zhao, Jing, et al.
Publicado: (2016)

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening
por: Clermont, Allen, et al.
Publicado: (2016)

Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology
por: Litts, Katie M., et al.
Publicado: (2016)

Choroidal Caverns: A Novel Optical Coherence Tomography Finding in Geographic Atrophy
por: Querques, Giuseppe, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_neupp7n7d043n2c9992l49g1c1