Cargando…

A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease

BACKGROUND: Chagas disease (CD) has significant global health impact, but safe, effective treatments remain elusive. The nitroimidazole fexinidazole is a potential treatment. METHODS: This double-blind, randomized, placebo-controlled, dose-finding, proof-of-concept study was conducted in Bolivia. Ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Torrico, Faustino, Gascón, Joaquim, Ortiz, Lourdes, Pinto, Jimy, Rojas, Gimena, Palacios, Alejandro, Barreira, Fabiana, Blum, Bethania, Schijman, Alejandro Gabriel, Vaillant, Michel, Strub-Wourgaft, Nathalie, Pinazo, Maria-Jesus, Bilbe, Graeme, Ribeiro, Isabela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Major Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907522/ https://www.ncbi.nlm.nih.gov/pubmed/35925555 http://dx.doi.org/10.1093/cid/ciac579

Ejemplares similares

Genetic polymorphism of Trypanosoma cruzi bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial
por: Ramírez, Juan Carlos, et al.
Publicado: (2021)

Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program
por: Valverde Mordt, Olaf, et al.
Publicado: (2022)

Innovative Partnerships for the Elimination of Human African Trypanosomiasis and the Development of Fexinidazole
por: Neau, Philippe, et al.
Publicado: (2020)

A strategy for scaling up access to comprehensive care in adults with Chagas disease in endemic countries: The Bolivian Chagas Platform
por: Pinazo, Maria-Jesus, et al.
Publicado: (2017)

Characterization of digestive disorders of patients with chronic Chagas disease in Cochabamba, Bolivia
por: Pinto, Jimy-Jose, et al.
Publicado: (2019)

Fexinidazole: A Potential New Drug Candidate for Chagas Disease
por: Bahia, Maria Terezinha, et al.
Publicado: (2012)

New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia
por: Alonso-Vega, Cristina, et al.
Publicado: (2021)

Results and evaluation of the expansion of a model of comprehensive care for Chagas disease within the National Health System: The Bolivian Chagas network
por: Pinazo, Maria-Jesus, et al.
Publicado: (2022)

A new patient registry for Chagas disease
por: Hotez, Peter, et al.
Publicado: (2020)

Multi-criteria decision analysis approach for strategy scale-up with application to Chagas disease management in Bolivia
por: Pinazo, Maria-Jesus, et al.
Publicado: (2021)

Usefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease
por: Parrado, Rudy, et al.
Publicado: (2019)

Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole
por: Watson, James A., et al.
Publicado: (2019)

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America
por: Picado, Albert, et al.
Publicado: (2018)

Strengthening the Bolivian pharmacovigilance system: New surveillance strategies to improve care for Chagas disease and tuberculosis
por: Cortes-Serra, Nuria, et al.
Publicado: (2020)

Rapid diagnostic tests duo as alternative to conventional serological assays for conclusive Chagas disease diagnosis
por: Egüez, Karina E., et al.
Publicado: (2017)

Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus
por: Alonso-Padilla, Julio, et al.
Publicado: (2020)

Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies
por: Tarral, Antoine, et al.
Publicado: (2014)

Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis
por: Ciapponi, Agustín, et al.
Publicado: (2020)

First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease
por: Ramírez, Juan C., et al.
Publicado: (2017)

Use of rapid diagnostic tests (RDTs) for conclusive diagnosis of chronic Chagas disease – field implementation in the Bolivian Chaco region
por: Lozano, Daniel, et al.
Publicado: (2019)

The Indeterminate Form of Chagas Disease
por: Issa, Victor Sarli
Publicado: (2018)

Indeterminate form of Chagas disease: historical, conceptual, clinical, and prognostic aspects
por: Hasslocher-Moreno, Alejandro Marcel, et al.
Publicado: (2021)

Letters to the Editor: Indeterminate form of Chagas Disease: some immunological insights
por: Hasslocher-Moreno, Alejandro Marcel, et al.
Publicado: (2022)

Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
por: Zingales, Bianca, et al.
Publicado: (2014)

Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi
por: Zuma, Aline Araujo, et al.
Publicado: (2022)

A tribute to Cecilio Romaña: Romaña’s sign in Chagas disease
por: Beucler, Nathan, et al.
Publicado: (2020)

Indeterminate Form of Chagas Disease: Some Immunological Insights
por: Matos, Daniel Mazza, et al.
Publicado: (2022)

Congenital Chagas Disease: Recommendations for Diagnosis, Treatment and Control of Newborns, Siblings and Pregnant Women
por: Carlier, Yves, et al.
Publicado: (2011)

In silico Design of an Epitope-Based Vaccine Ensemble for Chagas Disease
por: Michel-Todó, Lucas, et al.
Publicado: (2019)

Increased aortic stiffness in adults with chronic indeterminate Chagas disease
por: Valbusa, Filippo, et al.
Publicado: (2019)

Corrigendum: In silico Design of an Epitope-Based Vaccine Ensemble for Chagas Disease
por: Michel-Todó, Lucas, et al.
Publicado: (2020)

Immunosuppression and Chagas Disease: A Management Challenge
por: Pinazo, María-Jesús, et al.
Publicado: (2013)

Parasitological, serological and molecular diagnosis of acute and chronic Chagas disease: from field to laboratory
por: Schijman, Alejandro Gabriel, et al.
Publicado: (2022)

Right Ventricular Doppler Echocardiographic Study of Indeterminate Form of Chagas Disease
por: Furtado, Rogério Gomes, et al.
Publicado: (2015)

Metabolic and immunological evaluation of patients with indeterminate and cardiac forms of Chagas disease
por: Rocha, Ivonete Helena, et al.
Publicado: (2020)

Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2–3 trial
por: Kande Betu Kumesu, Victor, et al.
Publicado: (2022)

Biomarkers of therapeutic responses in chronic Chagas disease: state of the art and future perspectives
por: Pinazo, Maria-Jesus, et al.
Publicado: (2015)

Achievements and Challenges upon the Implementation of a Program for National Control of Congenital Chagas in Bolivia: Results 2004–2009
por: Alonso-Vega, Cristina, et al.
Publicado: (2013)

Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease
por: Martínez-Peinado, Nieves, et al.
Publicado: (2021)

Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study
por: Kande Betu Ku Mesu, Victor, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rbgbsb6jq8k2g053dqjsira1oq