A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the packaging of guideRNA-encoding lentiviral vector g...

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Detalles Bibliográficos
Autores principales: Hsieh, Emily, Janssens, Derek H., Paddison, Patrick J., Browne, Edward P., Henikoff, Steve, OhAinle, Molly, Emerman, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
https://www.ncbi.nlm.nih.gov/pubmed/36706161
http://dx.doi.org/10.1371/journal.ppat.1011101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
https://www.ncbi.nlm.nih.gov/pubmed/36706161
http://dx.doi.org/10.1371/journal.ppat.1011101

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