Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence

The Arp2/3 complex is an actin nucleator with well-characterized activities in cell morphogenesis and movement, but its roles in nuclear processes are relatively understudied. We investigated how the Arp2/3 complex affects genomic integrity and cell cycle progression using mouse fibroblasts containi...

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Detalles Bibliográficos
Autores principales: Haarer, Elena L., Theodore, Corey J., Guo, Shirley, Frier, Ryan B., Campellone, Kenneth G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907832/
https://www.ncbi.nlm.nih.gov/pubmed/36706133
http://dx.doi.org/10.1371/journal.pgen.1010045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9907832/
https://www.ncbi.nlm.nih.gov/pubmed/36706133
http://dx.doi.org/10.1371/journal.pgen.1010045

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