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Coordinated activity of a central pathway drives associative opioid analgesic tolerance
Opioid analgesic tolerance, a root cause of opioid overdose and misuse, can develop through an associative learning. Despite intensive research, the locus and central pathway subserving the associative opioid analgesic tolerance (AOAT) remains unclear. Using a combination of chemo/optogenetic manipu...
Autores principales: | Hou, Yiwen, Zou, Guichang, Wang, Xianglian, Guo, Hui, Ma, Xiao, Cheng, Xingyu, Xie, Zhiyong, Zuo, Xin, Xia, Jing, Mao, Huanhuan, Yuan, Man, Chen, Qi, Cao, Peng, Yang, Yupeng, Zhang, Li, Xiong, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908028/ https://www.ncbi.nlm.nih.gov/pubmed/36753548 http://dx.doi.org/10.1126/sciadv.abo5627 |
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