Pharmacologic inhibition by spironolactone attenuates experimental abdominal aortic aneurysms

BACKGROUND: Abdominal aortic aneurysms (AAA) are characterized by vascular inflammation and remodeling that can lead to aortic rupture resulting in significant mortality. Pannexin-1 channels on endothelial cells (ECs) can modulate ATP secretion to regulate the pathogenesis of AAA formation. Our hypo...

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Detalles Bibliográficos
Autores principales: Ladd, Zachary, Su, Gang, Hartman, Joseph, Lu, Guanyi, Hensley, Sara, Upchurch, Gilbert R., Sharma, Ashish K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908993/
https://www.ncbi.nlm.nih.gov/pubmed/36776267
http://dx.doi.org/10.3389/fcvm.2023.1101389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908993/
https://www.ncbi.nlm.nih.gov/pubmed/36776267
http://dx.doi.org/10.3389/fcvm.2023.1101389

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