Structure-guided design of a potent Clostridioides difficile toxin A inhibitor

Crystal structures of camelid heavy-chain antibody variable domains (V(H)Hs) bound to fragments of the combined repetitive oligopeptides domain of Clostridioides difficile toxin A (TcdA) reveal that the C-terminus of V(H)H A20 was located 30 Å away from the N-terminus of V(H)H A26. Based on this obs...

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Detalles Bibliográficos
Autores principales: Hussack, Greg, Rossotti, Martin A., van Faassen, Henk, Murase, Tomohiko, Eugenio, Luiz, Schrag, Joseph D., Ng, Kenneth K.-S., Tanha, Jamshid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909335/
https://www.ncbi.nlm.nih.gov/pubmed/36778856
http://dx.doi.org/10.3389/fmicb.2023.1110541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909335/
https://www.ncbi.nlm.nih.gov/pubmed/36778856
http://dx.doi.org/10.3389/fmicb.2023.1110541

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