Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD(+)/SIRT1 axis

BACKGROUND: Fibrosis is increasingly considered as a major contributor in adipose tissue dysfunction. Hypoxic activation of hypoxia-inducible factor 1α (HIF-1α) induces a profibrotic transcription, leading to adipose fibrosis. Nicotinamide mononucleotide (NMN), a member of the vitamin B(3) family, h...

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Detalles Bibliográficos
Autores principales: Wu, Keke, Li, Biao, Ma, Yingxu, Tu, Tao, Lin, Qiuzhen, Zhu, Jiayi, Zhou, Yong, Liu, Na, Liu, Qiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909340/
https://www.ncbi.nlm.nih.gov/pubmed/36777361
http://dx.doi.org/10.3389/fendo.2023.1099134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909340/
https://www.ncbi.nlm.nih.gov/pubmed/36777361
http://dx.doi.org/10.3389/fendo.2023.1099134

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